Hydrogen Peroxide

Legend: Pilot experiments showing the effects of a mild stressor (10-s tail pinch, TP) on the amperometric signals recorded in the striatum of a freely moving rat implanted with either a glutamate biosensor (Pt/PPD/GluOx) or a prototype H2O2 sensor (Pt/PPD/Albumin). The Pt/PPD/GluOx biosensor used recently in another pilot study that failed to detect glutamate changes associated with 10-s tail pinch, showed ca. 3-times lower in-vitro sensitivity to glutamate than the Pt/PPD/GluOx electrode used here. The calibration bar is for glutamate; the scale for the H2O2 sensor is ca. 10-times larger.